Importing data from XML file to SQL database

Question

Hey
Is it possible to import data from XML file to a SQL database, and if yes, how would that be done. I have a XML file that contains about 50 000 entries and I have to make an application that would manipulate that data (mostly reading and comparing) - so my concern is that the manipulation with that amount of data (and there is a very likely possibility that in the future there will be even more) would be very slow and inefficient. If there is some other option that you think would be better, please advise.
Thanks