Yes. You can mix hardware wallets and software wallets in the same multisig, and many teams do exactly that.

This is not a workaround or a compromise. It is a supported and very common setup.

A multisig wallet created with platforms like Safe does not care what type of wallet a signer uses. From the multisig’s point of view, every signer is just an address that can produce a valid signature. That signature might come from a Ledger, a Trezor, MetaMask, a mobile wallet, or even an institutional custody provider.

What matters is how you design the signer mix and the approval threshold.

In practice, teams often use a combination like this.
One or two hardware wallets for founders or core treasury holders.
One software wallet for day to day operations or speed.
Sometimes an institutional or backup signer for recovery scenarios.

This approach balances security and usability.

Hardware wallets are slower but extremely secure. Software wallets are faster and easier to access but more exposed. Mixing them allows teams to protect large movements of funds while still operating efficiently.

The key rule is this. Hardware wallets should control the majority of power.

For example, in a two of three multisig, at least two signers should be hardware wallets. That way, no transaction can be executed without offline approval. A software wallet alone can never move funds.

In a three of five setup, teams often require that at least two or three hardware wallet holders participate in every transaction. The software wallets help with coordination, not control.

Where people get into trouble is when convenience takes over. If most signers are software wallets and the threshold can be met without touching a hardware wallet, the multisig is technically valid but practically weak. At that point, you are one phishing attack away from a serious incident.

Another advantage of mixing wallets is resilience. If a hardware wallet holder is temporarily unavailable, a software wallet signer may still help meet the threshold without compromising security, assuming the design is sound.

Multisig wallets are governance tools. They reflect how you want decisions to be made, not just how transactions are signed. Mixing wallet types is part of that governance design.

The real question is not whether you can mix hardware and software wallets. You can. The real question is whether your setup forces hardware wallets to be involved when it actually matters.

If the answer is yes, you are using multisig the way it was intended.