ASP.NET 4.5 has not been registered on the Web server. You need to manually configure your Web server for ASP.NET 4.5 in order for your site to run correctly.

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To resolve this Open Visual Studio tools command prompt and execute below command:
aspnet_regiis -i

asutosh shinePosted Jul 6, 2017, 4:38 PM
How to resolve it? its quite frustrating again and again seeing the error dialog box when try to open an project .
Neha NarangPosted Dec 19, 2016, 6:00 AM
Still getting the same error
Santhakumar MunuswamyPosted May 1, 2015, 1:08 AM
i think, we have to specific target framework location full path like C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\aspnet_regiis.exe -I. I hope you doing well but if you added some more details to understand the concept with a beginner easily.