Web Application doesn't support Client Profile version of the Framework.
Microsoft has removed Client Profile from latest version of .NET Framework 4.5 and hence with .NET 4.5 there is no Client Profile as shown in the image below.
.NET Client Profile Vs. .NET Framework
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Nick ByrnesPosted Jan 30, 2013, 1:01 PM
Interesting post, I would be interested in more in depth information as to what makes the Client Profiles more lightweight than their full-featured counterparts and why .NET 4.5 doesn't have a Client Profile.