Asp.net

hi, this strongly depends on your needs. For simplier apps all the three will do the job, there are not any major differences. So pick one you are most familiar with. You can use MS Sql Server and MS Access out of the box, whereas for mysql you will have to download a connector. Otherwise you won't be able to connect from your code. Such installation is not a big deal though.

Here is an article I wrote few months ago about connecting to MySQL, it might be usefull for you: http://www.c-sharpcorner.com/UploadFile/f9f215/ado-net-and-mysql-connection/