how to protect my application by hard drive serial number.

Sorry to say, but your question makes no sense.

 

You could write the current serial into registry (or where ever) durng Installation and always check when starting ... but this will happen on every Installation so only a HDD change will corrupt this. => makes no sense

 

The only way you could somehow make it (kind of, remember reverse engeneering takes 5 secs) If you contact an external server storing the insallation and e.g. username and some guid or so, to generate a unique serial to be entered. This way the only way to get a valid serial is to contact your server.

 

Any other scenario using Hardware is nonsense.