Yes, when designing a data storage and management solution on Azure, it is generally recommended to use Azure Storage and Azure Data Lake Storage Gen1/Gen2 Metastore in the same region. There are several reasons why this is recommended:

Data Latency: By using storage resources in the same region, you can minimize data latency and improve data transfer speeds. When you transfer data between storage resources in different regions, it can increase the latency and affect the performance of your applications.

Compliance and Regulatory Requirements: If you need to comply with specific regulatory requirements or data sovereignty laws, it is often necessary to store data within a specific region. By using storage resources in the same region, you can ensure that your data is stored within the required geographic boundaries.

Network Traffic and Cost: When you transfer data between storage resources in different regions, it can generate network traffic and incur additional costs. By using storage resources in the same region, you can minimize network traffic and reduce data transfer costs.

Data Integration: When you use Azure Data Lake Storage Gen1/Gen2 Metastore, it can integrate with other Azure services, such as Azure Databricks, Azure HDInsight, and Azure Stream Analytics, to provide a comprehensive data storage and processing solution. By using storage resources in the same region, you can ensure that your data is available and accessible to these services without any data transfer or latency issues.