How to use local db for publish a site

Question

I have query in my mind.

 

1. I have used Microsoft technology (ASP.NET & SQL Server) for web development.

 

2.If we want to used db2/400 with the help of SQL or instant of SQL. But problem is web application (application server) is on public domain but IBM i (db2/400) is in local (not accessible out site of organisation).

 

Can anyone suggest which approach to use, or how to deal with this kind of situation for web development?