How to Fix Can't Open .EXE File's?

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Even if a Windows user is using the latest version of Windows, opening, and accessing .exe files can be difficult. Many related questions have been submitted to Microsoft forums, but no viable solution has been provided to resolve cannot open .exe files in Windows 10 OS issue.
When a user tries to open a .exe file, it can also receive an error message such as a denied access or a runtime error. what's the actual reason behind this question?
There are several ways to resolve this error. Here we will show you the most convenient way to open .exe files in Windows 10.
Open command prompt (Press Win+R & Type cmd)
Type regedit then press Enter
Registry Editor will open, click HKEY_CLASSES_ROOT.exe from left pane of screen
In Registry keys, click Default key and set data value to EXE file
After changing value, click HKEY_CLASSES_ROOTexefileshellopencommand key
Click Default key and change value to “%1” %*
Finally Restart Windows to fix the problem
After starting your PC in Safe Mode, press Windows + S to enter Windows Firewall and select Windows Firewall from there
In the left pane, click Enable or Disable Windows Firewall. in the wizard that opens, select Disable Windows Firewall for personal and public network settings and click ok to save your changes
After Disable Windows Firewall, see if the issue still exists or not.
1. Use System File Checker
This is a built-in tool that Microsoft provides users to repair data files. This software allows you to scan Windows and restore files.
2. Try a Clean Boot of the System
A clean startup is a process of getting Windows started with minimal programs and services. Also, if Windows starts with minimal resources, you can use the hit-and-trial method to find the third-party application that's affecting your files.
To start the system with a clean boot, you must run the msconfig command in the Run dialog box. this will bring up the System Configuration Utility.
Go to the Services tab, hide all Microsoft services and click the start tab to locate and disable the offending software. Now restart your system. That way you will not face the issue again.
3. Install the latest Update
Check for the latest Windows 10 updates and install them on your system. If you do not have the latest update, download and install it. this is because older versions may not be able to open .exe files.