Yes. You can change multisig signers after the wallet is created, and this flexibility is one of the biggest reasons teams use multisig wallets in the first place.
Multisig wallets are not frozen structures. They are designed to evolve as teams change, people rotate, and responsibilities shift.
When a multisig is created using platforms like Safe, the initial list of owners and the approval threshold are just the starting point. Those settings can be updated later through a multisig transaction, as long as the required number of existing signers approve the change.
This is an important detail. No single person can quietly add or remove signers. Any change to ownership or thresholds must go through the same approval process as moving funds. That keeps governance transparent and controlled.
In practice, changing signers usually happens for very normal reasons. A founder steps back. An advisor’s role ends. A hardware wallet is lost. A company restructures. None of these events should force a treasury migration or a full wallet reset.
Instead, the remaining signers submit a transaction to remove an old signer, add a new one, or adjust the approval threshold. Once approved, the multisig updates its internal rules and continues operating as usual.
This ability to rotate signers is one of the biggest differences between multisig wallets and single wallet setups. With a single wallet, losing access often means starting over. With multisig, loss and change are expected scenarios.
That said, this flexibility only works if the multisig was designed correctly from the start. If the threshold cannot be met without the signer you want to remove, the wallet becomes stuck. This is why two of two setups are risky for anything long term. They leave no room for recovery or governance changes.
Well designed multisigs assume change. They use thresholds like two of three or three of five so that the system can keep moving even when one signer is unavailable or needs to be replaced.
Another common use case is upgrading security. Teams often start with a mix of software and hardware wallets, then later move all signers to hardware wallets as value grows. Multisig makes this transition straightforward without moving funds.
The key idea is that multisig wallets are living systems. They reflect how a team governs assets over time, not just how transactions are approved today.
If your multisig setup cannot adapt to change, it is not finished. It is fragile.