This question usually comes up right after someone decides to take treasury security seriously. They understand multisig. They want to use hardware wallets. Then the next logical concern hits. Does this even work on the network we are using?
The short answer is yes, on most major networks.
The longer answer is that support depends on whether the network supports smart contracts and whether your multisig platform supports that chain.
Multisig wallets are smart contracts. That means they only work on networks that support smart contract execution. If a network does not support smart contracts, multisig in the modern sense is simply not possible there.
Platforms like Safe support multisig wallets across a wide range of EVM compatible networks. These are networks that follow the Ethereum Virtual Machine standard and behave similarly at the smart contract level.
Today, hardware wallet multisig works reliably on networks such as Ethereum mainnet, Polygon, Arbitrum, Optimism, Base, and several other EVM chains. If your hardware wallet can sign transactions on that network and Safe supports it, multisig works the same way as it does on Ethereum.
From the user’s point of view, nothing fundamental changes.
The multisig still has its own address.
The funds still live in the multisig contract.
Hardware wallets still sign approvals.
The only differences are gas fees, transaction speed, and network specific quirks.
This is another place where people get confused. They think hardware wallet support is about the multisig platform. It is not. Hardware wallets sign transactions at the wallet level. As long as the wallet supports the chain and the multisig contract exists on that chain, everything works.
Where limitations do show up is on non EVM chains. Some blockchains use completely different account models and smart contract systems. In those ecosystems, multisig may exist, but it is often implemented differently and may not integrate with the same tooling or hardware wallets in a familiar way.
That does not mean multisig is impossible there. It just means the experience is different and sometimes less mature.
For most teams today, especially those building DAOs, protocols, or company treasuries, EVM chains cover the vast majority of real world use cases. That is why Safe has become the default standard. It works the same way across networks, which reduces operational risk.
One practical thing to keep in mind is that each network has its own multisig deployment. Your Ethereum multisig is not the same as your Polygon multisig. They are separate contracts, even if they use the same signers. Funds must be moved to each network’s multisig independently.
The takeaway is straightforward.
If your network supports smart contracts and Safe supports that network, you can use hardware wallet multisig there.
If it does not, you need to evaluate that ecosystem’s native multisig options carefully.
Multisig security scales best on networks where tooling is mature. Network choice is not just about performance or fees. It is also about how safely you can manage assets long term.