how to make a simple game in c#

jayjay I agree with Dorababu in that you need to be more specific as to which type of game you want to make, but if you want power and simplicity I would suggest to start with the XNA framework. Mike wrote a good article (http://www.c-sharpcorner.com/UploadFile/mgold/XNAIntro04192007233237PM/XNAIntro.aspx) about getting started and the starter kits are also a big help.

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