ASP.NET applications can only run on Windows operating systems,
ASP.NET Core is designed to be cross-platform and can run on Windows, macOS, and Linux.

ASP.NET applications are typically deployed as full .NET Framework applications
ASP.NET Core applications can be deployed as self-contained applications or using the .NET Core runtime.

ASP.NET Core is generally faster and more lightweight than ASP.NET due to its modular architecture and optimized runtime.

ASP.NET Core has built-in support for dependency injection, while in ASP.NET you need to use a third-party library for this feature.

ASP.NET Core uses a middleware pipeline to handle requests, which allows for more granular control over the request handling process.
ASP.NET, we use HttpModules and HttpHandlers to handle requests

ASP.NET Core has a more flexible and streamlined configuration system compared to ASP.NET, which allows for easier configuration of the application at runtime.

ASP.NET Core introduces a new web application model called Razor Pages, which simplifies the creation of page-focused web applications.
In ASP.NET We can’t able to add C# logic in aspx page .

These are some of the key differences between ASP.NET and ASP.NET Core. Which framework to choose depends on the specific requirements of your project and the development team’s expertise.