Can I use SqlHelper Class with MYSQLDB

for that you have use mysql connecter or dll to be referenced to your project.

http://dev.mysql.com/downloads/connector/net/

No, you can not use without any modifications in sqlhelper class file.
SQLhelper.cs file is only meant for sql server, if you want to use it for mysql, you need to create a new one.

http://www.c-sharpcorner.com/UploadFile/8af3e0/connecting-to-mysql-using-C-Sharp-net/


http://dev.mysql.com/doc/connector-net/en/connector-net-ref-mysqlclient-mysqlhelper.html

http://code.ohloh.net/search?s=MYSQL%20server%20helper%20class&pp=0&fl=C%23&fe=cs&mp=0&ml=1&me=0&md=1&ff=1&filterChecked=true