Extremely ambiguous error

You running Whidbey? I'm having all kinds of problems that didn't occur until I installed it. To debug, ASPNET just has to be part of domain users and can be part of Debugger Users, correct? Am I missing something? There's a new user ASPNET_WEB_ADMIN that creates a web server on the fly to run your test app in--of course MS wasn't trying to add any levels of complexity... :-)

run a program :) it won't launch any .Net apps, so I'm re-installing the framework now...

What are you trying to do?