How to close an excel application if it is already opened ?.

protected virtual bool IsFileinUse(FileInfo file)
{
FileStream stream = null;
try
{
stream = file.Open(FileMode.Open, FileAccess.ReadWrite, FileShare.None);
}
catch (IOException)
{
//the file is unavailable because it is:
//still being written to
//or being processed by another thread
//or does not exist (has already been processed)
return true;
}
finally
{
if (stream != null)
stream.Close();
}
return false;
}