Non-Standard Windows

Question

Hi -- not sure how to phrase this and it's probably not a very specific question. 

I was wondering if its possible to create an application in VS-2008 Standard with an irregular form frame -- something like XNormal or like many of the audio/video players?

It's easy to create one inside a standard Windows form using a png image with transparency, but is there a way to do this as the main form?

Hope my question is not too confusing.