Cadence, a leader in electronic design automation technology, has launched the Millennium M2000 Supercomputer, a breakthrough system designed to accelerate engineering and life sciences applications. The new supercomputer, available both in the cloud and on-premises, is powered by NVIDIA’s latest Blackwell architecture, including the NVIDIA HGX B200 systems and NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs-alongside the powerful NVIDIA CUDA-X software libraries.

According to Cadence, the Millennium M2000 delivers up to 80 times higher performance for electronic design automation, system design, and life sciences workloads compared to its CPU-based predecessor. This leap in computational capability enables engineers and researchers to run massive simulations, driving innovation in fields ranging from autonomous machines and semiconductor design to drug discovery and data center optimization.

Collaboration with NVIDIA: AI Factories and Digital Twins

The announcement was made at CadenceLIVE in Santa Clara, where Cadence President and CEO Anirudh Devgan joined NVIDIA founder and CEO Jensen Huang onstage. Devgan highlighted the years-long collaboration, emphasizing the synergy between NVIDIA’s hardware advances and Cadence’s software optimization.

This is years in the making. It’s a combination of advancement on the hardware and system side by NVIDIA and then, of course, we have to rewrite our software to take advantage of that.

Devgan said during the conversation with Huang

The work that we’re doing together recognizes that there’s a whole new type of factory that’s necessary. We call them AI factories. AI is going to infuse into every single aspect of everything we do. Every company will be run better because of AI, or they’ll build better products because of AI.

Huang

Transforming Engineering Across Industries

The Millennium M2000 leverages accelerated software from both NVIDIA and Cadence, supporting a broad spectrum of applications such as circuit simulation, computational fluid dynamics, data center design, and molecular modeling. With its optimized hardware and AI-driven software, the supercomputer empowers users to build more complex simulations and gain faster, more accurate insights-enabling rapid advances in silicon, systems, and pharmaceutical development.

Cadence and NVIDIA are also pioneering the use of AI factories and digital twins. The Cadence Reality Digital Twin Platform, integrated with the NVIDIA Omniverse Blueprint, allows engineering teams to simulate and optimize power, cooling, and networking in AI factories before physical construction begins. This capability enables faster, more informed configuration decisions and helps future-proof next-generation AI infrastructure.

Real-World Impact: Faster Simulations and Smarter Design

NVIDIA’s engineering teams have already used Cadence Palladium emulation and Protium prototyping platforms to support the development of the Blackwell architecture. Cadence, in turn, used NVIDIA Grace Blackwell-accelerated systems to run highly complex fluid dynamics simulations for aerospace applications in under 24 hours, a task that would take several days on traditional CPU clusters.

The Millennium M2000 also integrates NVIDIA BioNeMo NIM microservices into Cadence’s Orion molecular design platform and NVIDIA Llama Nemotron reasoning models into the Cadence JedAI Platform, further expanding its capabilities for AI-powered research and design.

The Future of AI-Driven Engineering

By combining cutting-edge hardware, advanced AI software, and deep collaboration, Cadence and NVIDIA are setting a new standard for intelligent design across industries. The Millennium M2000 Supercomputer is poised to enable breakthroughs in everything from chip design and autonomous systems to drug discovery and digital twin simulation-ushering in a new era of accelerated innovation.