Microsoft Office Word(doc) file Manipulation problme in asp.net

Question

Hi,
I have developed asp.net based Diagnostic Application,that I have one table NameHistopath(id,gross_appearance,dx,appearance) I have a MS doc file name sample.doc.
sample.doc will receive 4 parameter(patient_id,name,Dr_name,contact_no)from UI under button event.
This sample.doc contain other text file also. 
Firstly I want to save this 4 parameter into sample.doc,copy this data and save it another file and file name will be according patient_id.


N.Bnew file will be generate each and every time under event click and I have to search file from folder according patient_id.(Is it better to use XML in this criteria) 
Any help make me grateful.
Masud